PROJECTS

ONGOING:

  1. Sreenivasa Reddy D. Usefulness of 128-slice multidetector computed tomography in diagnosis of coronary artery disease in patients       with chest pain and negative or nondiagnostic exercise treadmill test result.

  2. Kiran Kumar K. Study of correlation between CHA2DS2-VASc score, SYNTAX score and carotid intima –media thickness in patients with  coronary artery disease.

  3. Narendra Ch. Role of Real-time trans thoracic three dimensional echocardiography score (RT-TT3DE score) in predicting the immediate outcomes of percutaneous transvenous mitral commissurotomy (PTMC).

  4. VinodKumar N. Correlation of clinical risk scores with angiographic extent of coronary artery disease in patients with non ST-elevation myocardial infarction /unstable angina and their effects on 6 months outcomes.

  5. Suresh babu T. Value of resting and stress myocardial deformation assessment by two dimensional speckle tracking echocardiography to predict the presence, extent and localization of coronary artery affection in patients with suspected stable coronary artery disease.

  6. Sumanth Reddy P. Effect of Percutaneous balloon mitral valvuloplasty on six minute walk test and left ventricular performance by speckle tracing echocardiography in rheumatic severe mitral stenosis.

  7. Praveen Kumar Reddy S. Right ventricular strain, strain rate and pulmonary function before and after percutaneous balloon mitral valvuloplasty in patients with severe mitral stenosis.

  8. Naganarasimha Reddy M. Value of ST-Segment elevation in lead aVR in non ST elevation myocardial Infarction/unstable angina in predicting disease extent, severity and outcomes at 3 months.

  9. Sowjenya G. Genetic polymorphism of Cytochrome P450 is associated with endothelial dysfunction in patients with coronary artery disease (Ph.D Thesis).

  10. Sreedhar Naik K. Genetic polymorphism of LTA, BAT1 and NFKBIL1 genes in patients with myocardial infarction (Ph.D. Thesis).

  11. Comparison of outcomes witheverolimus eluting stents: Xience Pro vs Everoflex.

  12. Incidence and features of spontaneous coronary artery dissection/coronary ectasia.

  13. PDA device closure: LV function analysis related to BNP.

COMPLETED:

  1. Correlation of syntax score, epicardial fat thickness and carotid intima medial thickness.

  2. New Echocardiographic parameters to predict PTMC outcomes.

  3. Correlation of Vitamin-D levels with angiographic severity in CAD patients.

  4. Study of efficacy and resistance of Thienopyridine antiplatelet drugs in Indian patients undergoing PCI and to study genetic polymorphisms of ABCB1 gene in patients found to have resistance to Clopidogrel.

  5. Study of polymorphisms of MTHFR, IL-6 and ICAM-1 genes in patients with coronary artery disease.

  6. Genetic polymorphism of Cytochrome P450 is associated with endothelial dysfunction in the patients with coronary artery disease.

  7. Genetic polymorphism of LTA, BAT1 and NFKBIL1 genes in patients with myocardial infarction.

  8. Assessment of correlation between CT coronary calcium scoring and carotid intimal medial thickness with angiographic severity.

  9. Study of spontaneous Echo contrast, mitral annular systolic velocity, LAALEV before and after PTMC in patients with sinus rhythm.

  10. eGFR, contrast volume, predicting outcomes in PCI.

  11. N-terminal proBNP and Tissue Doppler imaging in diastolic heart failure (DM thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2012.

  12. Effect of percutaneous mitral balloon valvuloplasty on left atrial appendage function: Transesophageal echo study(DM thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2012.

  13. The Real World Experience of Biodegradable Polymer-Coated Sirolimus-Eluting Coronary Stent System: Results from an “All-Comers” Single Centre Clinical Experience.

  14. Single Centre Experience and Outcome of Primary Percutaneous Coronary Intervention for patients with ST Segment Elevation Myocardial Infarction.

  15. Safety and efficacy of sirolimus-eluting stent in diabetic patients compared with non-diabetic patients undergoing percutaneous coronary intervention.

  16. Clinical outcomes from unselected real-world patients with acute myocardial infarction receiving biodegradable polymer coated sirolimus-eluting stents.

  17. Clinical and Thrombotic profile of patients presenting with symptomatic Pulmonary embolism (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2013.

  18. Primary percutaneous coronary intervention in STEMI immediate and intermediate outcomes (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2013.

  19. Impact of successful percutaneous transluminal mitral valve commissurotomy on right ventricular function (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2013.

  20. Evaluation of characteristics, predictors and clinical implications of iatrogenic atrialseptal defects after PTMC with real time 3 dimensional echocardiography (RT3DE) (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2013.

  21. Profile and outcomes of ST elevation Myocardial Infarction patients presenting to Sri VenkateswaraInstitute of Medical Sciences in 2013 (SVIMS STEMI Registry).

  22. The prognostic significance of N-terminal proBNP, 3D LA dyssynchrony in patients with acute ST-elevation myocardial infarction (STEMI) undergoing Primary Percutaneous Coronary Intervention (PCI) (DM Theis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2014.

  23. Assessments of RV function by 2D and 3D echocardiography before and after ASD device closures (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2014.

  24. Plasma N-terminal proBNP levels as a marker of adequacy of valvotomy in patients with rheumatic mitral stenosis (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2014.

  25. Study of the relationship between metabolic syndrome score and angiographic severity of coronary artery disease (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2014.

  26. Correlation of NTproBNP levels with severity of acute pulmonary embolism (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2015.

  27. The correlation of NT-proBNP with echocardiographic indices including 3D vena contracta width in the assessment of severity of MR (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2015.

  28. Predictive value of D-dimer and mitral annular systolic velocity for detection of LAA thrombus in patients with mitral stenosis and sinus rhythm (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2015.

  29. Comparative study of aortic velocity propagation by color M-mode of descending thoracic aorta (AVP) with Carotid intima media thickness (CIMT) as a non-invasive marker of atherosclerosis (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences; 2015.
     

 

CLINICAL TRIALS:

ONGOING:

1.  A randomized, double-blind, placebo-controlled, event-driven trial of quarterly subcutaneous canakinumab in the prevention of recurrent cardiovascular events among stable-post-MI patients with elevated hsCRP.

2.  Global Anticoagulant Registry In the FIELD (GARFIELD): Prospective, multicentre, international Registry of male and female patients newly diagnosed with atrial fibrillation.

COMPLETED:

1. A  phase 2 Randomized, double blind, placebo controlled, parallel group, dose response study of PF – 00489791, acute hemodynamic effect in  subjects with primary pulmonary Hypertension.

2. An International multi center randomized double blind study to compare the overall mortality in acutely ill medical patients treated with enoxaparin vs placebo in addition to graduated elastic stockings.

3. RUBY-1 study, A randomized double blind placebo controlled multi center parallel group study of safety  tolerability and efficacy of YM150 in combination with standard treatment in secondary prevention of ischemic vascular events in subjects with acute coronary syndromes.

4. H7T-MC-TABY(b) study :A comparison of Prasugrel and clopidogrel in acute coronary syndrome subjects with Unstable angina? Non ST Elevation Myocardial infarction who are medically managed TRIOLOGY ACS study.

5.  DU 176b-D-U305_HOKUSAI VTE: a phase-III randomized, double blind, parallel group, multi-center, multi-national study for evaluation of efficacy and safety of (LMW)Heparin/Edoxaban versus (LMW)Heparin/Warfarin in subjects with symptomatic deep vein thrombosis and /or pulmonary embolism.

 

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