1.      Identification of Tyrosine kinase and Serine/Threonine kinase activities in Staphylococcus aureus ATCC12600. Indian Patent filed: TR-5. C.B.R. NO: 6535.



Gene/Protein sequences deposited in GenBank: 109.


Book Chapter Published

Sarma PVGK and Sivakumar V (2010) “The Diagonsis of Autosomal Dominant Polycystic Kidney Disease”. Chapter written in the book Polycystic Kidney Disease, edited by K.V. Dakshinamurthy, ECAB clinical update Nepherology.  ELESEVIER publications.

Papers presented in National/International conferences:  94

Papers published

1.      Sarma PV, Sarma PU, Murthy PS. Isolation, purification and characterization of intracellular calmodulin like protein (CALP) from Mycobacterium phlei. FEMS Microbiol Lett. 1998;1;159(1):27-34. (PMID:9485591).

2.      Sarma PV, Purkayastha S, Madan T, Sarma PU. Expression of an epitopic region of AspfI, an allergen/antigen/cytotoxin of Aspergillus fumigatus. Immunol Lett. 1999;70(3):151-5. (PMID:10656667).

3.      Sarma PU, Sarma PV, Madan T. Challenges in prevention, diagnosis and therapy of emerging fungal diseases. Aspergillosis: A case study. Indian J Clin Biochem. 2000 Aug;15(Suppl 1):43-50. (PMID:23105267).

4.      Nigam S, Sarma PVGK, Ghosh PC, Sarma PU. Characterization of Aspergillus fumigatus protein disulfide isomerase family gene. Gene. 2001;281(1-2):143-50. (PMID:11750136).

5.      Kumar, Ashok, Kumar, Satish, Sarma, PVGK. and Sharma, A. K. Differential Conformational Environment of Tryptophan in Epsilon Native Prototoxin and Active Toxin From Clostridium Perfringens Type D'. Journal of Biochemistry, Mol.Biol.& Biophys., 2002;6(2):147-150. (PMID: 12186772).

6.      Sarma PVGK, Subramanyam G. In vitro cardiogenesis can be initiated in human CD34+ cells. Indian Heart J. 2008;60(2):95-100. (PMID: 19218716).

7.      Manjunath M, Sarma PVGK, Reddy OVS. In vitro Evaluation of antibacterial activity of Actiniopteris radiata (Sw.)Link. Journal of pharmacy and chemistry. 2008;2(2):112-118.

8.      Sarma PVGK, Hari Prasad O, Prasad UV, Manohar Reddy M, Kumar Swamy Reddy K, Subramanyam G. Purification and characterization of Human Intestinal alkaline phosphatase and its role in the colonization of Helicobacter pylori in the duodenum. Current Trends in Biotechnology and Pharmacy. 2009;3(4):390-396.

9.      Himakar Reddy K, Bala Nagi Reddy K, Sarma PVGK, Reddy OVS. In vitro Studies on Antimicrobial and Antioxidant Activities of Dillenia indica Seed Extract. Journal of Pure and Applied Microbiology. 2009;3(2):769-776.

10.  Naresh VVS, Reddy ALK, Sivaramakrishna G, Sarma PVGK, Vardhan RV, Siva Kumar V. Angiotensin converting enzyme gene polymorphism in type II diabetics with nephropathy. Indian Journal of Nephrology. 2009;19(4):145-148. (PMID: 20535249).

11.  Naresh VV, Reddy AL, Sivaramakrishna G, Sarma PV, Vardhan RV, Kumar VS. Angiotensin converting enzyme gene polymorphism in type 2 diabetics with nephropathy. Indian J Nephrol. 2010;20(2):119.(PMID: 20835335).

12.  Himakar Reddy K, Tharanath V, Nagi Reddy KB, Sarma PVGK, Reddy OVS. Studies on hepatoprotective effect of hexane extract of Dillenia indica against CCl 4 induced toxicity and its safety evaluation in wistar albino rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2010;1(3):441–50.

13.  Reddy KH, Sharma PV, Reddy OV. A comparative in vitro study on antifungal and antioxidant activities of Nervilia aragoana and Atlantia monophylla. Pharm Biol. 2010;48(5):595-602.(PMID: 20645805).

14.  Hariprasad O, Gopinath VP, Navya A, Yugandhar VG, Sarma PVGK. Particulate vaccine for bacterial diseases. International Journal of Drug Discovery. 2010;2(2):17-19.

15.  Hari Prasad O, Nagarjuna V, Lakshmi Prasanna Ch, Vasu D, Yugandhar VG, Venkateswar Prasad U, Srinivas Rao PVLN, Abhijit Chaudhary, Reddy OVS, Sarma PVGK. UV light Induces Transposition of blaZ gene resulting in high expression of B-lactamase in a clinical isolate of Staphylococcus aureus sensitive to amipicillin. Journal of pure and Applied Microbiology. 2010;4(2):609-616.

16.  Hari Prasad O, Navya A, Vasu D, Chiranjeevi T, Bhaskar M, Sreedhar Babu K.V, Sarma P.V.G.K. Protective effects of Prosopis juliflora against Staphylococcus aureus induced hepatotoxicity in rats. Int J Pharm Biomed Res 2011;2(3):172-178.

17.  Kumar YN, Kumar PS, Sowjenya G, Rao VK, Yeswanth S, Prasad UV, Pradeepkiran JA, Sarma PV, Bhaskar M. Comparison and correlation of binding mode of ATP in the kinase domains of Hexokinase family. Bioinformation. 2012;8(12):543-7.(PMID: 22829728).

18.  Himabindu G, Rajasekhar D, Latheef K, Sarma PV, Vanajakshamma V, Chaudhury A, Bitla AR. Factor V Leiden mutation is not a predisposing factor for acute coronary syndromes. Indian Heart J. 2012;64(6):570-5. (PMID:23253409).

19.  Siddhartha Kumar B, Sarma PV, Lava Kumar Reddy, B. Manoj Prajwal, Alladi Mohan and V. Siva Kumar (2012). Mutation analysis of PKD1 gene in Indian population. Saudi J.Kidney.Dis. Transpl 23(1), 143-147.  (PMID: 22237240).

20.  Santhosh Kumar P, Srinivasa Rao V, Abdul K, Prasad UV, Nanda kumar Y, Sarma PVGK. Validation, quantitative and qualitative analysis of felodipine drug using HPLC. Journal of Pharmacy Research. 2012;5(4):1838-1840.

21.  Hari Prasad O, Nanda Kumar Y, Reddy OV, Chaudhary A, Sarma PV. Cloning, expression, purification and characterization of UMP kinase from Staphylococcus aureus. Protein J. 2012;31(4):345-52. (PMID: 22528139).

22.  Nanda Kumar Y, Kalpana K, Venkateswara Swamy K, Sarma PVGK, M. Bhaskar. Molecular dynamics simulations of MODY 2 mutated Glucokinase structures revealed significant conformational variations explaining reasons for hyperglycemic condition. Int J Pharm Bio Sci, 2012;3(4):(B)493–499.

23.  Venkatesh K, Reiner G, Debral AK, Kirpan P, Reers M, Murthy PVVS, Swarupa V, Srikanth L, Sarma PVGK. “pH Optimization and Production of High Potent Cellular Vaccine by Bordetella pertussis”. International Journal of Biotechnology and Bioengineering Research 2012;3(1):17-25.

24.  Venkatesh K, Srikanth L, Swarupa V, Yeswanth S, Prasad UV, Vasu D, Vishnuvardhan GP, Srinivas P, Santhoshkumar P, Sowjenya G, Nandakumar Y, Chaudhary A, Sarma PVGK. Isolation, purification and characterization of pyruvate kinase from Staphylococcus aureus: a potential drug target. J Clin Sci Res 2012;1:76-82.

25.  Srikanth L, Ramaiah J, Venkatesh K, Sriram P, Tejachandra G, Kannan T, Sarma PVGK. Differential Expression of ADH and ALDH2 can be a Diagnostic Marker in Gastroesophageal Cancer. Current Trends in Biotechnology and Pharmacy 2012;6(1):112-118.

26.  Swathi S, Rizwana S, Anjan Babu G, Santhosh Kumar P, Sarma PVGK. Classification of Neural network structures for Breast cancer diagnosis. International Journal of Computer Science and Communication, 2012;3(1):227-231.

27.  Santhosh Kumar P, Jayanthi B, Abdul K, Prasad UV, Nanda Kumar Y, PVGK Sarma. A Validated High performance liquid chromatography (HPLC) Method for the Estimation of Cefuroxime axetil. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2012;3(3), 223-228.

28.  Nanda Kumar Y, Pradeep Kiran JA, Santhosh Kumar P, Yeswanth S, Kalpana K, Koteswara Rao V, Sarma PVGK, Bhaskar M. Molecular docking assessment of pyridone derivatives as glucokinase activators. J Clin Sci Res 2012;1:163-73.

29.  K. Himakar Reddy, Patrick Govender, O. V. S. Reddy, P.V. G. K. Sarma. Effect of hexane extract of Dillenia indica seed on the activity of secreted aspartyl proteinase of Candida albicans and its kinetic studies. Journal of Medicinal Plants Research. 2012;6(44),5599-5603.

30.  Rathnakar Reddi KVN, Santhosh Kumar P, Venkateswara Prasad U, Yeswanth S, Swarupa V, Vasu D, Venkatesh K, Srikanth L, Nanda Kumar Y, Sarma PVGK. Isolation, purification and characterization of glucokinase from Staphylococcus aureus. Journal of pharmacy research 2013;6:205-209.

31.  Yellapu NK, Kandlapalli K, Valasani KR, Sarma PV, Matcha B Structural Variations of Human Glucokinase Glu256Lys in MODY2 Condition Using Molecular Dynamics Study. Biotechnol Res Int. 2013;2013:264793. (PMID: 23476789).

32.  Prasad UV, Vasu D, Kumar YN, Kumar PS, Yeswanth S, Swarupa V, Phaneendra BV, Chaudhary A, Sarma PV. Cloning, Expression and Characterization of NADP-Dependent Isocitrate Dehydrogenase from Staphylococcus aureus. Appl Biochem Biotechnol. 2013;169(3):862-9. (PMID: 23288593).

33.  Lakshmi HP, Prasad UV, Yeswanth S, Swarupa V, Prasad OH, Narasu ML, Sarma PV. Molecular characterization of α-amylase from Staphylococcus aureus. Bioinformation. 2013;9(6):281-5. (PMID: 23559746).

34.  Swarupa V, Yeswanth S, Prasad UV, Vasu D, Venkatesh K, Srikanth L, Anitha P, Manasa C, Santhosh Kumar P, Sowjenya G, Nandakumar Y, Chaudhary A, PVGK Sarma. Characterization of succinate dehydrogenase flavoprotein from Staphylococcus aureus ATCC 12600. J Clin Sci Res 2013;2:81-87.

35.  Lakshmi HP, Yeswanth S, Prasad UV, Vasu D, Swarupa V, Kumar PS, Narasu ML, Krishna Sarma PVGK. Cloning, expression and characterization of glucokinase gene involved in the glucose-6- phosphate formation in Staphylococcus aureus. Bioinformation. 2013;9(4):169-73. (PMID: 23519063).

36.  Hari Prasad O, Nanda Kumar Y, Santhosh Kumar P, Reddy OVS, Chaudhary A, PVGK Sarma. Staphylococcus aureus TMPK and TK showing distinct structural differences with human TMPK and TK:A probable explanation in the pathogenesis. Journal of pharmacy research. 2013;7(1):1-7.

37.  Santhosh Kumar P, Venkatesh K, Srikanth L, Sarma PVGK, Reddy AR, Subramanian S, Phaneendra BV. Novel three missense mutations observed in Von  Hippel-Lindau gene in a patient reported with renal cell carcinoma; Indian Journal of Human Genetics, 2013;19(3): 373-376. (PMID: 24339559)

38.  Venkatesh K, Srikanth L, Vengamma B, Chandrasekhar C, Sanjeevkumar A, Mouleshwara Prasad BC, Sarma PVGK. In vitro differentiation of cultured human CD34+ cells into astrocytes. Neurol India 2013;61:383-388. (PMID: 24005729).

39.  Kishore KA, Hari Prasad O, Sudheer A, Mohan K, Vinay C, Chiranjeevi P, Bhaskar M, Sarma PVGK., Papa Rao A, Reddy R. Identification of predominant subgingival microbes in acute myocardial infarction patients of South Indian population. Journal of Indian college of cardiology, 2013;3:104-110.

40.  Yeswanth S, Kumar YN, Prasad UV, Swarupa V, Koteswara Rao V, Sarma PVGK. Cloning and Characterization of L - Lactate dehydrogenase gene of Staphylococcus aureus, Anaerobe 2013;24:43-48. (PMID: 24036421).

41.  Yeswanth S, Lalith Kumar CH, Swarupa V, Prasad U.V,Vasu D, Nanda Kumar Y, Srikanth L, Venkatesh K, Sowjenya G, Santhosh kumar P, Kavya D, Chaudhary A, Sarma PVGK. Characterization of Inosine Monophosphate Dehydrogenase from Staphylococcus aureus ATCC12600 and its involvement in biofilm formation, J Clin Sci Res 2013;2:203-10.

42.  Swarupa V, Sundari R, Prasad UV, Yeswanth S, Sarma PVGK. Induced mutagenesis in Staphylococcus aureus ATCC 12600 resultinKg over expression of Streptomycin 3''-adenylyltransferase1, Journal of Pure and Applied Microbiology. 2013; 7(3) 2417-2422.

43.  PVGK Sarma, L.Srikanth, K. Venkatesh, P.S.N.Murthy, P.Usha Sarma. Isolation, purification and characterization of cardiolipin synthase from Mycobacterium phlei. Bioinformation.2013; 9(13): 690-695. PMID: 23930021.

44.  Santhosh Kumar P, Venkatesh K, Srikanth L, Prasad UV, Syama Sundar T, Ram Prasad Reddy A, Tyagi A, Radhika K, Sarma PVGK. Novel frame shift mutations (‘A’ deletion) observed in exon 9 ofWilms' tumor (WT1) gene in a patient reported with glomerulosclerosis. Gene 2014;546, 63–67. (PMID: 24853201).

45.  Yellapu N, Mahto MK, Valasani KR, Sarma PVGK, Matcha B. Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding - explains hyperglycemia in type 2 diabetic patients. J Biomol Struct Dyn. 2014;15:1-14. ( PMID: 24720358).

46.  Kumar YN, Rao VK, Kumar PS, Sowjenya G, Sarma PVGK, Bhaskar M. Identification and analysis of novel R308K mutation in Glucokinase of type2 diabetic patient and its kinetic correlation. Biotechnology and Applied Biochemistry 2014: 61(5): 572-581. (PMID: 24447076).

47.  Kumar YN, Navya A, Kalpana K, Ravendra Babu K, Jhansi Rani V, Hariprasad O, Nagaraju C, Sarma PVGK, Bhaskar M. Design, synthesis, in silico, and in vitro evaluation of novel pyrimidine phosphonates with cytotoxicity against breast cancer cells. Med Chem Res 2014 23: 317-328.

48.  Chiranjeevi T, Hari Prasad O, Prasad UV, Kumar AK, Praveen Chakravarthi V, Balaji Rao P, Sarma PVGK, Reddy N, Reddy R, Bhaskar M. Identification of Microbial Pathogens in Periodontal disease and Diabetic patients of South Indian Population. Bioinformation 2014;10(4): 241-244. (PMID: 24966528).

49.  Santhosh Kumar P, Kumar YN, Prasad UV , Yeswanth S, Swarupa V, Sowjenya G, Venkatesh K, Srikanth L, Rao VK, Sarma PVGK. In silico designing and molecular docking of a potent analog against Staphylococcus aureus porphobilinogen synthase. Journal of Pharmacy and Bioallied Sciences July-September 2014; 6 (3), 158-166. (PMID: 25035635)

50.  Prasad UV, Swarupa V, Yeswanth S, Kumar PS, Kumar ES, Reddy KMK, Kumar YN, Jhansi Rani V, Chaudhary A, Sarma PVGK. Structural and Functional analysis of Staphylococcus aureus NADP-dependent IDH and its comparison with Bacterial and Human NADP dependent IDH. Bioinformation 2014;10(2):081-086.

51.  Santhosh Kumar P, Kumar YN, Prasad UV , Yeswanth S, Swarupa V, Venkatesh K, Srikanth L, Rao VK, Sarma PVGK. Comparative Structural and Functional Analysis of Staphylococcus aureus Glucokinase with other Bacterial Glucokinases. Indian Journal of Pharmaceutical Sciences 2014; 76(5):430-436 (PMID: 25425757)

52.   Prasad UV, Vasu D, Yeswanth S, Swarupa V, Sunitha MM, Choudharry A, Sarma PVGK. Phosphorylation controls the functioning of Staphylococcus aureus Isocitrate dehydrogenase - favours biofilm formation. J Enzyme Inhib Med Chem. 2015;30(4):655-61. [PMID: 25744510]  

53.  Vasu D, Sunitha MM, Srikanth L, Swarupa V, Prasad UV, Sireesha K, Yeswanth S, Kumar PS, Venkatesh K, Chaudhary A, Sarma PVGK. In Staphylococcus aureus the regulation of Pyruvate kinase activity by serine/threonine protein kinase favors biofilm formation. 3 Biotech. 2015; 5(4): 505–512.

54.  Swarupa V, Sundari RA, Prasad UV, Yeswanth S, Prasad OH, Sarma PVGK. Identification of methicillin resistant Staphylococcus aureus in raw cow milk through amplification of mecA. Journal of Pure and Applied Microbiology. 2014; 8(6).

55.  Pasupuleti Santhosh Kumar, Katari Venkatesh, Gopal Sowjenya, Lokanathan Srikanth, M.M Sunitha, U. Venkateswara Prasad, V. Swarupa, S. Yeswanth, P Sri Ram Naveen, A Sridhar, V Siva Kumar and Sarma PVGK. Mutations in exons 3 and 7 resulting in truncated expression of human ATP6V1B1 gene showing structural variations contributing to poor substrate binding- causative reason for distal renal tubular acidosis with sensorineural deafness. J Biomol Struct Dyn. 2015;33(10):2094-103. [PMID: 25517796]

56.  Venkatesh K, Srikanth L, Vengamma B, Chandrasekhar C, Mouleshwara Prasad BC, Sarma PVGK (2015). In vitro transdifferentiation of Human cultured CD34+ stem cells into Oligodendrocyte precursors using Thyroid hormones. Neuroscience Letters. 588; 36-41. [PMID: 25549541]

57.   Parvathina Sriram Naveen, Lokanatha Srikanth, Katari Venkatesh, Potukuchi Venkata Gurunadha Krishna Sarma, Naga Sridhar, Chennu Krishnakishore, Yanala Sandeep, Yadla Manjusha, Vishnubhotla Sivakuma (2015). Distal Renal Tubular Acidosis with Nerve Deafness Secondary to ATP6B1 Gene Mutation. Saudi J Kidney Dis Transpl. 26(1):119-121. [PMID: 25579729]

58.  Srikanth L, Venkatesh K, Sunitha MM, Kumar PS, Chandrasekhar C, Vengamma B, Sarma PV. In vitro generation of type-II pneumocytes can be initiated in human CD34+ stem cells. Biotechnol Lett. 2015 Oct 16. [PMID: 26475269]

59.  Srikanth L, Sunitha MM, Venkatesh K, Kumar PS, Chandrasekhar C, Vengamma B, Sarma PV. Anaerobic Glycolysis and HIF1α Expression in Haematopoietic Stem Cells Explains Its Quiescence. Nature. Journal of stem cells. 2015;10:97-106.

60.  Himakar Reddy Kandappa, Karen Pillay, Vijaya Sarathi Reddy Obulam, Potukuchi Venkata Gurunadha Krishna Sarma and Patrick Govender (2015). In vitro Antifungal, Antioxidant and Cytotoxic Activities of a Partially Purified Protein Fraction from Atlantia monophylla Linn (Rutaceae) Leaf. Tropical Journal of Pharmaceutical Research. 2015;14 (3):487-493.

61.  Venkateswara Prasad U, Vasu D, Rishi Gowtham R, Krishna Pradeep Ch, Swarupa V, Yeswanth S, Abhijit Choudhary, Sarma P. V. G. K. Cloning, expression and characterization of NAD Kinase from Staphylococcus aureus involved in the formation of NADP (H)- a key molecule in the maintaining of redox status and biofilm formation. Advanced Biomedical Research. (In Press).

62.  Anju Verma, Sarella Jotho Bai, Sarma PVGK, Nagraj M, Srikant L, Vasavi B, Chandramouli P, Usha Kalawat. Prevalence of hepatitis C virus infection and its genotypes among the blood donors at Tirupati, Andhra Pradesh. Journal of clinical and Scientific Research (in Press).

63.  Swathi S, Santhosh Kumar P, Sarma P.V.G.K. Approach of Jordan Elman Neural Network to Diagnose Breast Cancer on Three Different Data Sets. International Journal of Advanced Research in Computer and Communication Engineering. 2015;4(11):321-325.






Copyright © 2010 Sri Venkateswara Institute of Medical Sciences. All rights reserved.
Hosted by National Informatics Centre