Present
a)
Research Projects completed in 2020:
i.
Screening of employees of SVIMS hospital (a tertiary care
hospital) aged </=40 years for their health status. Funding
Agency: SBAVP, SVIMS. Total Grant:Rs. 23,39,460. Principal
Investigator Vanajakshamma V.
ii.
Effects of successful
percutaneous transvenous mitral commissurotomy on acute and
intermediate term aortic stiffness in critical rheumatic
mitral stenosis. Principal Investigator Dr. M. Rajanaga
Mahesh.
iii.
Electrocardiographic
identification of the culprit coronary artery and correlation
with angiographic culprit lesion in patients with acute ST
elevation myocardial infarction. Principal Investigator Dr.
Nagaraja Reddy Challa.
iv.
Correlation of spot urine protein
creatinine ratio with angiographic disease severity in non
diabetic stable coronary artery disease. Principal
Investigator DR. B. Raghuram.
v.
Left ventricular global
longitudinal strain following revascularization in acute ST
elevation myocardial infarction – A comparison of primary
angioplasty and fibrinolytic therapy. Principal Investigator
Dr. V. Ravindra dev.
b)
Ongoing research projects:
Dr. D. Rajasekhar as principle investigator.
i.
SVIMS has enrolled as a sub centre under the nodal centre
JIPMER in the National Heart Failure Registry of ICMR with
Dr. D. Rajasekahr as principal Investigator.
ii.
The Impact of Heart Failure on Household Economic Well-Being
– SVIMS has enrolled as a sub centre for the ICMR Study with
Dr. D. Rajasekahr as principal Investigator.
1.
Research Work:
i)
Thesis Work:
Completed:
1.
Chandana V. Spectrum of Congenital Heart diseases and its
correlation with maternal risk factors. (M.Sc. Echo). Tirupati:
Sri Venkateswara Institute of Medical Sciences; 2020.
Ongoing:
1.
Vijaya Chandra Reddy
K. Effect of Heartfulness Meditation Practices on endothelial
function and inflammation in patients with coronary artery
disease (PhD). (as Chief Guide)
ii)
Thesis in progress:
a)
G. Rampavan Kumar. Assessment of right ventricular strain and
strain rate before and after ASD device closure.
b)
P. Chandrasekhar Reddy. Assessment of left ventricular function
by myocardial strain imaging in cancer patients before and after
chemotherapy.
c)
Y. Madhava Naidu. Utility of global longitudinal strain and
strain rate imaging to identify potential coronary artery
disease in patients with subclinical left ventricular systolic
dysfunction.
d)
Dr. P. Venkata Harish. Association of Testosterone with the
Angiographic severity of coronary artery disease in the middle
age males.
e)
Dr. B. Kiran. Correlation between ASCVD score, ankle brachial
index and CT calcium score with severity of coronary artery
disease on coronary angiogram.
f)
Dr. K. Sriram. Echocardiographic assessment of right ventricular
function in inferior wall myocardial infraction and angiographic
correlation with right coronary artery disease.
g)
Dr. V. Varunmitra. Echocardiographic assessment of inter and
intraventricular dyssynchrony in heart failure patients with
reduced ejection fraction and normal QRS duration using speckle
tracking, tissue Doppler imaging, 2D Echocardiography and
M-mode.
Previous
ONGOING:
1.
Sreenivasa Reddy D. Usefulness of 128-slice
multidetector computed tomography in diagnosis of coronary artery
disease in patients with chest pain and negative or nondiagnostic
exercise treadmill test result.
2.
Kiran Kumar K. Study of correlation
between CHA2DS2-VASc score, SYNTAX score and carotid intima –media
thickness in patients with coronary artery disease.
3.
Narendra Ch. Role of Real-time trans
thoracic three dimensional echocardiography score (RT-TT3DE score)
in predicting the immediate outcomes of percutaneous transvenous
mitral commissurotomy (PTMC).
4.
VinodKumar N. Correlation of clinical
risk scores with angiographic extent of coronary artery disease in
patients with non ST-elevation myocardial infarction /unstable
angina and their effects on 6 months outcomes.
5.
Suresh babu T. Value of resting and
stress myocardial deformation assessment by two dimensional
speckle tracking echocardiography to predict the presence, extent
and localization of coronary artery affection in patients with
suspected stable coronary artery disease.
6.
Sumanth Reddy P. Effect of Percutaneous
balloon mitral valvuloplasty on six minute walk test and left
ventricular performance by speckle tracing echocardiography in
rheumatic severe mitral stenosis.
7.
Praveen Kumar Reddy S. Right ventricular
strain, strain rate and pulmonary function before and after
percutaneous balloon mitral valvuloplasty in patients with severe
mitral stenosis.
8.
Naganarasimha Reddy M. Value of
ST-Segment elevation in lead aVR in non ST elevation myocardial
Infarction/unstable angina in predicting disease extent, severity
and outcomes at 3 months.
9.
Sowjenya G. Genetic polymorphism of
Cytochrome P450 is associated with endothelial dysfunction in
patients with coronary artery disease (Ph.D Thesis).
10.
Sreedhar Naik K. Genetic polymorphism of
LTA, BAT1 and NFKBIL1 genes in patients with myocardial infarction
(Ph.D. Thesis).
11.
Comparison of outcomes with everolimus eluting stents: Xience Pro
vs Everoflex.
12.
Incidence and features of spontaneous coronary artery
dissection/coronary ectasia.
13.
PDA device closure: LV function analysis related to BNP.
1.
Correlation of syntax score, epicardial fat thickness and carotid
intima medial thickness.
2.
New Echocardiographic parameters to predict PTMC outcomes.
3.
Correlation of Vitamin-D levels with angiographic severity in CAD
patients.
4.
Study of efficacy and resistance of Thienopyridine antiplatelet
drugs in Indian patients undergoing PCI and to study genetic
polymorphisms of ABCB1 gene in patients found to have resistance
to Clopidogrel.
5.
Study of polymorphisms of MTHFR, IL-6 and ICAM-1
genes in patients with coronary artery disease.
6.
Genetic polymorphism of Cytochrome P450 is associated with
endothelial dysfunction in the patients with coronary artery
disease.
7.
Genetic polymorphism of LTA, BAT1 and NFKBIL1 genes in patients
with myocardial infarction.
8.
Assessment of correlation between CT coronary calcium scoring and
carotid intimal medial thickness with angiographic severity.
9.
Study of spontaneous Echo contrast, mitral annular systolic
velocity, LAALEV before and after PTMC in patients with sinus
rhythm.
10.
eGFR, contrast volume, predicting outcomes in PCI.
11.
N-terminal proBNP and Tissue Doppler imaging in diastolic heart
failure (DM thesis). Tirupati: Sri Venkateswara Institute of
Medical Sciences; 2012.
12.
Effect of percutaneous mitral balloon valvuloplasty on left atrial
appendage function: Transesophageal echo study(DM thesis).
Tirupati: Sri Venkateswara Institute of Medical Sciences; 2012.
13.
The Real World Experience of Biodegradable Polymer-Coated
Sirolimus-Eluting Coronary Stent System: Results from an
“All-Comers” Single Centre Clinical Experience.
14.
Single Centre Experience and Outcome of Primary Percutaneous
Coronary Intervention for patients with ST Segment Elevation
Myocardial Infarction.
15.
Safety and efficacy of sirolimus-eluting stent in diabetic
patients compared with non-diabetic patients undergoing
percutaneous coronary intervention.
16.
Clinical outcomes from unselected real-world patients with acute
myocardial infarction receiving biodegradable polymer coated
sirolimus-eluting stents.
17.
Clinical and Thrombotic profile of patients presenting with
symptomatic Pulmonary embolism (DM Thesis). Tirupati: Sri
Venkateswara Institute of Medical Sciences; 2013.
18.
Primary percutaneous coronary intervention in STEMI immediate and
intermediate outcomes (DM Thesis). Tirupati: Sri Venkateswara
Institute of Medical Sciences; 2013.
19.
Impact of successful percutaneous transluminal mitral valve
commissurotomy on right ventricular function (DM Thesis). Tirupati:
Sri Venkateswara Institute of Medical Sciences; 2013.
20.
Evaluation of characteristics, predictors and clinical
implications of iatrogenic atrialseptal defects after PTMC with
real time 3 dimensional echocardiography (RT3DE) (DM Thesis).
Tirupati: Sri Venkateswara Institute of Medical Sciences; 2013.
21.
Profile and outcomes of ST elevation Myocardial Infarction
patients presenting to Sri VenkateswaraInstitute of Medical
Sciences in 2013 (SVIMS STEMI Registry).
22.
The prognostic significance of N-terminal proBNP, 3D LA
dyssynchrony in patients with acute ST-elevation myocardial
infarction (STEMI) undergoing Primary Percutaneous Coronary
Intervention (PCI) (DM Theis). Tirupati: Sri Venkateswara
Institute of Medical Sciences; 2014.
23.
Assessments of RV function by 2D and 3D echocardiography before
and after ASD device closures (DM Thesis). Tirupati: Sri
Venkateswara Institute of Medical Sciences; 2014.
24.
Plasma N-terminal proBNP levels as a marker of adequacy of
valvotomy in patients with rheumatic mitral stenosis (DM Thesis).
Tirupati: Sri Venkateswara Institute of Medical Sciences; 2014.
25.
Study of the relationship between metabolic syndrome score and
angiographic severity of coronary artery disease (DM Thesis).
Tirupati: Sri Venkateswara Institute of Medical Sciences; 2014.
26.
Correlation of NTproBNP levels with severity of acute pulmonary
embolism (DM Thesis). Tirupati: Sri Venkateswara Institute of
Medical Sciences; 2015.
27.
The correlation of NT-proBNP with echocardiographic indices
including 3D vena contracta width in the assessment of severity of
MR (DM Thesis). Tirupati: Sri Venkateswara Institute of Medical
Sciences; 2015.
28.
Predictive value of D-dimer and mitral annular systolic velocity
for detection of LAA thrombus in patients with mitral stenosis and
sinus rhythm (DM Thesis). Tirupati: Sri Venkateswara Institute of
Medical Sciences; 2015.
29.
Comparative study of aortic velocity propagation by color M-mode
of descending thoracic aorta (AVP) with Carotid intima media
thickness (CIMT) as a non-invasive marker of atherosclerosis (DM
Thesis). Tirupati: Sri Venkateswara Institute of Medical Sciences;
2015.
CLINICAL TRIALS:
ONGOING:
·
1. A randomized, double-blind, placebo-controlled, event-driven
trial of quarterly subcutaneous canakinumab in the prevention of
recurrent cardiovascular events among stable-post-MI patients with
elevated hsCRP.
·
2. “Global Anticoagulant Registry In the FIELD (GARFIELD):
Prospective, multicentre, international Registry of male and
female patients newly diagnosed with atrial fibrillation.
·
1. A phase 2 Randomized, double blind, placebo controlled,
parallel group, dose response study of PF – 00489791, acute
hemodynamic effect in subjects with primary pulmonary
Hypertension.
·
2. An International multi center randomized double blind study to
compare the overall mortality in acutely ill medical patients
treated with enoxaparin vs placebo in addition to graduated
elastic stockings.
·
3. RUBY-1 study, A randomized double blind placebo controlled
multi center parallel group study of safety tolerability and
efficacy of YM150 in combination with standard treatment in
secondary prevention of ischemic vascular events in subjects with
acute coronary syndromes.
·
4. H7T-MC-TABY(b) study :A comparison of Prasugrel and
clopidogrel in acute coronary syndrome subjects with Unstable
angina? Non ST Elevation Myocardial infarction who are medically
managed TRIOLOGY ACS study.
·
5. DU 176b-D-U305_HOKUSAI VTE: a phase-III randomized, double
blind, parallel group, multi-center, multi-national study for
evaluation of efficacy and safety of (LMW)Heparin/Edoxaban versus
(LMW)Heparin/Warfarin in subjects with symptomatic deep vein
thrombosis and /or pulmonary embolism.
